North American Society For Pediatric Gastroenterology, Hepatology & Nutrition

Inflammatory Bowel Disease

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Adult Sentinel Articles

SONIC: Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease

 Colombel JF, Sandborn WJ, Reinisch W, Mantzaris GJ, Kornbluth A, Rachmilewitz D, Lichtiger S, D'Haens G, Diamond RH, Broussard DL, Tang KL, van der Woude CJ, Rutgeerts P; SONIC Study Group. N Engl J Med. 2010 Apr 15;362(15):1383-95. doi: 10.1056/NEJMoa0904492. PMID:20393175

ACCENT 1: Maintenance Infliximab for Crohn's Disease: The ACCENT I Randomised Trial

 Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, Rachmilewitz D, Wolf DC, Olson A, Bao W, Rutgeerts P; ACCENT I Study Group. Lancet. 2002 May 4;359(9317):1541-9. PMID:12047962

ACT 1 & 2: Infliximab for Induction and Maintenance Therapy for Ulcerative Colitis

 Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns J, Travers S, Rachmilewitz D, Hanauer SB, Lichtenstein GR, de Villiers WJ, Present D, Sands BE, Colombel JF.N Engl J Med. 2005 Dec 8;353(23):2462-76. Erratum in: N Engl J Med. 2006 May 18;354(20):2200. PMID:16339095

CESAME Lymphoma Study: Lymphoproliferative Disorders in Patients Receiving Thiopurines for Inflammatory Bowel Disease: A Prospective Observational Cohort Study

 Beaugerie L, Brousse N, Bouvier AM, Colombel JF, Lémann M, Cosnes J, Hébuterne X, Cortot A, Bouhnik Y, Gendre JP, Simon T, Maynadié M, Hermine O, Faivre J, Carrat F, for the CESAME Study Group. Lancet. 2009 Nov;374:1617–25. PMID:19837455

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis (GEMINI 1)

 PMID 23964932

Pediatric Sentinel Articles

6MP: Multicenter Trial of 6-Mercaptopurine and Prednisone in Children with Newly Diagnosed Crohn's Disease

 Markowitz J, Grancher K, Kohn N, Lesser M, Daum F.A Gastroenterology. 2000 Oct;119(4):895-902.PMID:11040176

REACH Trial (Infliximab for Pediatric CD) Induction and Maintenance Infliximab Therapy for the Treatment of Moderate-to-Severe Crohn's Disease in Children

 Hyams J, Crandall W, Kugathasan S, et al. Gastroenterology. 2007;132(3):863-73.

IMAGINE Trial (Adalimumab for Pediatric CD) Induction and Maintenance Adalimumab for Moderate to Severe Crohn's Disease in Children: A Randomized Double-Blind Trial

 Hyams J,Griffiths AM, Markowitz J et al Gastroenterology 2011;140:S90.

T72 study: Induction and Maintenance Therapy with Infliximab for Children with Moderate to Severe Ulcerative Colitis

Hyams J, Damaraju L, Blank M, Johanns J, Guzzo C, Winter HS, Kugathasan S, Cohen S, Markowitz J, Escher JC, Veereman-Wauters G, Crandall W, Baldassano R, Griffiths A; T72 Study Group. Clin Gastroenterol Hepatol. 2012 Apr;10(4):391-9.e1. doi: 10.1016/j.cgh.2011.11.026. Epub 2011 Dec 8. PMID:22155755

Methotrexate in Pediatric IBD: Retrospective Cohort Study of Methotrexate Use in the Treatment of Pediatric Crohn's Disease

 Sunseri W, Hyams JS, Lerer T, Mack DR, Griffiths AM, Otley AR, Rosh JR, Carvalho R, Grossman AB, Cabrera J, Pfefferkorn MD, Rick J, Leleiko NS, Hitch MC, Oliva-Hemker M, Saeed SA, Kappelman M, Markowitz J and Keljo DJ, For the Pediatric Inflammatory Bowel Disease Collaborative Research Group IBD 2014 Aug;20(8):1341-5. PMID:24983976

Multi-Center Experience of Vedolizumab Effectiveness in Pediatric Inflammatory Bowel Disease

 PMID 27542130

Infliximab Dosing Strategies and Predicted Trough Exposure in Children with Crohn Disease

 PMID 26890885

Practical Use of Infliximab Concentration Monitoring in Pediatric Crohn Disease

 PMID 26551317

Factors Associated with Early Outcomes Following Standardized Therapy in Children with Ulcerative Colitis (PROTECT): A Multicentre Inception Cohort Study

 PMID 28939374

Pediatric Review Articles

Health Maintenance and Vaccination Strategies in Pediatric Inflammatory Bowel Disease

 Breglio KJ, Rosh JR. Inflamm Bowel Dis. 2013 Jul;19(8):1740-4. doi: 10.1097/MIB.0b013e318281f5b5. Review. PMID: 2368980

Balancing and Communicating the Risks and Benefits of Biologics in Pediatric Inflammatory Bowel Disease

 Dulai PS, Siegel CA, Dubinsky MC. Inflamm Bowel Dis. 2013 Dec;19(13):2927-36. PMID:23867874

Epidemiology of Pediatric Inflammatory Bowel Disease: A Systematic Review of International Trends

 Benchimol EI, Fortinsky KJ, Gozdyra P, Van den Heuvel M, Van Limbergen J, Griffiths AM. Inflamm Bowel Dis. 2011 Jan;17(1):423-39. PMID:20564651.

ImproveCareNow: The Development of a Pediatric Inflammatory Bowel Disease Improvement Network

 Crandall W, Kappelman MD, Colletti RB, Leibowitz I, Grunow JE, Ali S, Baron HI, Berman JH, Boyle B, Cohen S, del Rosario F, Denson LA, Duffy L, Integlia MJ, Kim SC, Milov D, Patel AS, Schoen BT, Walkiewicz D, Margolis P. Inflamm Bowel Dis. 2011 Jan;17(1):450-7. PMID:20602466.

Pediatric Modification of the Montreal Classification for Inflammatory Bowel Disease: The Paris Classification

 Levine A, Griffiths A, Markowitz J, Wilson DC, Turner D, Russell RK, Fell J, Ruemmele FM, Walters T, Sherlock M, Dubinsky M, Hyams JS. Inflamm Bowel Dis 2011;17:1314–1321. PMID:21560194.

Disease Activity Indices

PCDAI

 PMID:16205508

Weighted PCDAI

 PMID:21351206

PUCAI

 PMID:19161178

SES-CD

 PMID:15472670

Mayo Endoscopic Score

 PMID:3317057

UCEIS

 PMID:21997563

NASPGHAN Guidelines/Position Statements

Diagnosis and Treatment of Perianal Crohn Disease: NASPGHAN Clinical Report and Consensus Statement

 2013

Health Supervision in the Management of Children and Adolescents With IBD: NASPGHAN Recommendations

 2012

Psychosocial Issues in Pediatric Inflammatory Bowel Disease: Report of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

 2013

Self-Management in Pediatric Inflammatory Bowel Disease: A Clinical Report of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

 2013

Use of Enteral Nutrition for the Control of Intestinal Inflammation in Pediatric Crohn Disease

 2012

Skeletal Health of Children and Adolescents With Inflammatory Bowel Disease

 2011

Role of Thiopurine Metabolite Testing and Thiopurine Methyltransferase Determination in Pediatric IBD

 2013

Guidelines/Position Statements

ECCO - Pediatric Acute Severe Ulcerative Colitis

 PMID:21224839

ECCO - Management of Pediatric Ulcerative Colitis

 PMID:22773060

ECCO – Outcome Measures for Clinical Trials in Pediatric IBD

 PMID:24821616

NASPGHAN IBD Monograph Series

Improving the Transition Process for Pediatric IBD Patients

Optimizing Therapeutic Safety in Children and Young Adults with IBD

Improving Health Supervision in Children and Young Adults with IBD

Changing Paradigms for Assessing Response to Therapy in Crohn's Disease

Enteral Nutrition as First Line Therapy in Treating Children and Adolescents with Crohn's Disease

NASPGHAN CME Podcast Series

Challenging Aspects of the IBD Transition Process

Enteral Nutrition as Primary Therapy for Crohn's Disease: Making it Happen for Pediatric Patients

NASPGHAN Video Series – Conferences

2011 Virtual IBD: Ulcerative Colitis

2013 Virtual IBD: Crohn's Disease

NASPGHAN Clinical Reports

NASPGHAN Clinical Report: Surveillance, Diagnosis and Prevention of Infectious Diseases in Pediatric Patients with Inflammatory Bowel Disease Receiving Tumor Necrosis Factor-a Inhibitors

 PMID 27027903

Hepatic Issues and Complications Associated with Inflammatory Bowel Disease: A Clinical Report from the NASPGHAN Inflammatory Bowel Disease and Hepatology Committees

 PMID 27984347

NASPGHAN Clinical Report on Postoperative Recurrence in Pediatric Crohn Disease

 PMID 28937552

The Role of Combination Therapy in Pediatric Inflammatory Bowel Disease: A Clinical Report from the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

 PMID 29210919

Assuring Quality for Non-Hospital-based Biologic Infusions in Pediatric Inflammatory Bowel Disease: A Clinical Report from the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

 PMID 29324477

CCFA Resources
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The information provided on this site is intended solely for educational purposes and not as medical advice. It is not a substitute for care by a trained medical provider. GIKids is not engaged in the provision or practice of medical, nursing, or health care advice or services. For advice about a disease, please consult a physician.

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