2015 Meeting Presentations

Patterns of NAFLD around the world
Jeff Schwimmer MD, University of California, San Diego

Putting NAFLD in perspective: An overview of the pathophysiology
Brent A. Neuschwander‐Tetri MD, St. Louis University

Genetics plus the environment: The sugar effect on PNPLA3
Michael Goran MD, Keck School of Medicine, University of Southern California

NAFLD andhttps://naspghan.org/ Type II Diabetes
Sonia Caprio MD, Yale University School of Medicine

Maternal insulin resistance and NAFLD development
Jed Friedman MD, University of Colorado School of Medicine

Fatty acid dysregulation in NAFLD
Elizabeth Parks MD, University of Missouri School of Medicine

Fructose and the liver: More than just extra calories?
Rob Lustig MD, University of California, San Francisco

Microbiome and NAFLD in children
Marialena Mouzaki MD, The Hospital for Sick Children

Genetics and NAFLD: What we know so far
Nicola Santoro MD, Yale University School of Medicine

Crosstalk between adipocytes and hepatocytes
Nitika Gupta MD, Emory University

Oxidized lipids and linoleic acid in NASH
Christopher Ramsdam MD, National Institutes of Health

Sterile inflammation and cell death
Ariel Feldstein MD, University of California, San Diego

NASH: What's bile got to do with it?
Rohit Kohli MD, Cincinnati Children's Hospital Medical Center

What dose of exercise reduces insulin resistance in children and application to NAFLD
Catherine Davis MD, Georgia Regents University

Interventions and policies to prevent obesity among vulnerable children
Jennifer Woo Baidal MD, Boston Children's Hospital

Prevention and treatment of childhood obesity: What can we learn and apply to prevention of NAFLD?
Sarah Barlow MD, Baylor College of Medicine

Goals of the NASH CRN and opportunities for collaboration
Joel Lavine MD, Columbia University

NIDDK priorities and perspectives
Ed Doo MD, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Opportunities for Collaboration
Veronica Miller PhD, Director, Forum for Collaborative HIV Research and The Liver Forum

FULMINANT COLITIS: DO WE NEED TO CHANGE OUR CURRENT PARADIGM? 
Jeffrey Hyams MD and Brendan Boyle MD

FUNCTIONAL ABDOMINAL PAIN: IMPLEMENTING NONPHARMACOLOGIC THERAPIES INTO YOUR PRACTICE 
Bruno Chumpitazi MD and Miranda Van Tilburg PhD

RECALCITRANT GER
Benjamin Gold MD and Hayat Mousa MD

EoE AND ELIMINATION DIETS
Amir Kagalwalla MD and Sally Schwartz RD

PUTTING ASSESSMENT OF ENDOSCOPIC COMPETENCE INTO PRACTICE 
Catharine Walsh MD and Jenifer Lightdale MD

FORMULA MANAGEMENT AND ENTERAL FEEDING
Valeria Cohran MD and Monique L Goldschmidt MD

ACUTE PANCREATITIS: BASIC MANAGEMENT AND BEYOND
Aliye Uc MD and Bradley Barth MD

DOLOR ABDOMINAL FUNCTIONAL: TODOS LOS ESTUDIOS SON NORMALES, PERO EL DOLOR SEVERO CONTINÚA. ¿AHORA QUE HAGO? (No charge)
Samuel Nurko MD and Jose Garza MD

BASIC SCIENCE YEAR IN REVIEW
Nicola Jones MD, PhD, The Hospital for Sick Children

CLINICAL SCIENCE YEAR IN REVIEW
William Balistreri MD, Cincinnati Children’s Hospital Medical Center

THE EOE HUNGER GAMES: PPI-REE IS CATCHING FIRE! 
Edaire Cheng MD, UT Southwestern Medical Center

USE OF CONCOMITANT IMMUNOMODULATORS AND ANTI-TNFS: EMERGING INSIGHTS 
Laurie Conklin MD, Children’s National Medical Center

INTRACTABLE CONSTIPATION: WHAT IS NEXT WHEN YOU ARE STUCK?
Jose Garza MD, Children’s Center for Digestive Healthcare, Atlanta

WHEN THE GOING GETS TOUGH: IMPROVING OUTCOMES OF COLONOSCOPY
Jenifer Lightdale MD, UMass Memorial Children’s Hospital

NASPGHAN Endoscopy Prize
SELF-ASSESSMENT ACCURACY OF PEDIATRIC ENDOSCOPISTS: A PROSPECTIVE CROSS SECTIONAL STUDY.
Catharine M. Walsh¹, Simon C. Ling¹, Jenifer R. Lightdale², Petar Mamula³, Heather Carnahan⁴. ¹Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Hospital for Sick Children, Toronto, ON, Canada; ²Division of Pediatric Gastroenterology and Nutrition, UMass Memorial Children's Medical Center, Worcester, MA, USA; ³Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA; ⁴School of Human Kinetics and Recreation, Memorial University of Newfoundland, St. John's, NF, Canada.

POLYPECTOMY: WHO, WHEN, WHY AND HOW 
Seth Septer MD, Children’s Mercy Hospital

UTILITY OF ROUTINE COLONIC BIOPSIES DURING PEDIATRIC COLONOSCOPIC POLYPECTOMY FOR BENIGN JUVENILE INFLAMMATORY POLYPS.
Michael A. Malandra, Sunpreet Kaur, Ashish Chogle. Gastroenterology, Hepatology, and Nutrition, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.

LONG TERM COMPLICATIONS OF TPN: NOW THAT MY INTESTINAL FAILURE PATIENTS ARE NOT DYING OF LIVER DISEASE, WHAT ELSE SHOULD I WORRY ABOUT? 
Jane Balint MD, Nationwide Children’s Hospital

NASPGHAN Nutrition Prize
ETHANOL LOCK THERAPY IN CHILDREN WITH INTESTINAL FAILURE: INFECTION PREVENTION AND VASCULAR PRESERVATION.
Danielle Wendel¹, Anne Reilly^1,2, Susan Coffin^1,2, Maria Mascarenhas^1,2, Millie Boettcher¹, Cynthia Wildes¹, Natalie Terry^1,2, Joy Collins^1,2, Christina Bales^1,2. ¹Children's Hospital of Philadelphia, Philadelphia, PA, USA;²University of Pennsylvania, Philadelphia, PA, USA.

COMBATING CLABSIS-PREVENTING CENTRAL LINE INFECTIONS AND OTHER CENTRAL LINE CHALLENGES
John Kerner MD, Lucile Packard Children’s Hospital

NASPGHAN Foundation/Nestle Nutrition Young Investigator Development Award
UNRAVELING METABOLIC DYSADAPTATION IN MALNUTRITION: FROM CELLULAR MECHANISMS TO IMPROVED CHILD SURVIVAL
Robert Bandsma, The Hospital for Sick Children, Toronto, ON

DEMYSTIFYING THE IND
Kerry Jo Lee MD, Food and Drug Administration
Kevin Bugin MD, Food and Drug Administration

THE INVESTIGATOR AS SPONSOR
James Heubi MD, Cincinnati Children’s Hospital and Medical Center

POST-OPERATIVE MANAGEMENT IN PEDIATRIC CROHN’S DISEASE: HOW SHOULD THE PEDIATRIC GASTROENTEROLOGIST APPROACH THIS IN 2015?
Sandy Kim MD, Nationwide Children’s Hospital

INFLIXIMAB DOSING STRATEGIES AND TROUGH EXPOSURE IN CHILDREN WITH CROHN'S DISEASE
Adam Frymoyer, K. T. Park. Stanford University, Palo Alto, CA, USA.

STATE OF THE ART RESEARCH LECTURE - VERY EARLY ONSET IBD IN CHILDREN: CAUSES, CURES, & CONUNDRUMS
Scott Snapper MD, Boston Children’s Hospital

INCREASED EXPRESSION OF LRRK2, A SUSCEPTIBILITY GENE OF IBD RESULTS IN SUPPRESSION OF AUTOPHAGY AND ENHANCED INNATE IMMUNE RESPONSES MEDIATING COLITIS.
Tetsuya Takagawa^1,2, Masaki Tajima¹, Kazutoshi Hori², Shiro Nakamura², Atsushi Kitani¹, Ivan J. Fuss¹, Warren Strober¹. ¹Mucosal Immunity, National Institutes of Health, Bethesda, MD, USA; ²Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya, Japan

SHOCKING THE GASTROINTESTINAL TRACT: ELECTRICAL STIMULATION FROM TOP TO BOTTOM
Steve Teich MD, Nationwide Children’s Hospital

STUDY OF PEG 3350 IN PEDIATRIC POPULATION.
Kent Williams¹, Lynette Rogers², Han Yin², Ivor Hill¹, John Barnard^1,2, Christopher Coss³, Carlo DiLorenzo¹.¹Pediatric Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, OH, USA;²The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; ³College of Pharmacy, The Ohio State University, Columbus, OH, USA.

STATE OF THE RESEARCH ART LECTURE - BUGGING THE GASTROINTESTINAL TRACT: MICROBIOME AND THE ENTERIC NERVOUS SYSTEM 
Elyanne Ratcliffe MD, McMaster University

NASPGHAN Foundation/George Ferry Young Investigator Award
DEFINING THE ROLE OF GLIAL CELLS IN THE ENTERIC NERVOUS SYSTEM
Meenakshi Rao MD, PhD, Columbia University Medical Center

BACTERIAL OVERGROWTH IN PEDIATRIC SHORT BOWEL SYNDROME
Conrad Cole MD, Cincinnati Children’s Hospital Medical Center

THE BACTERIAL COMMUNITY OF THE SMALL INTESTINE IN CHILDREN WITH SHORT BOWEL SYNDROME. 
Brittany E. Goldberg¹, Steven Zeichner³, Emmanuel Mongodin⁴, John Huang³, Clarivet Torres². ¹Pediatric Infectious Diseases, Children's National Medical Center, Washington, DC, USA; ²Intestinal Rehabilitation Program, Children's National Medical Center, Washington, DC, USA; ³Center for Cancer and Immunology Research, Children's National Medical Center, Washington, DC, USA; ⁴Institute for Genome Sciences, University of Maryland, Baltimore, MD, USA.

STATE OF THE RESEARCH ART LECTURE - CUTTING EDGE OR CRAZY: IS SURGERY THE MOST EFFECTIVE TREATMENT FOR NASH?
Stavra Xanthakos MD, Cincinnati Children’s Hospital Medical Center

NASPGHAN Foundation/Takeda Pharmaceuticals Products, Inc Research Innovation Award
NASH IMPROVEMENT AFTER BARIATRIC SURGERY: THE ROLE OF BILE ACID SIGNALING
Rohit Kohli MD, Cincinnati Children’s Hospital Medical Center

SWALLOWING PROBLEMS IN INFANTS AND TODDLERS: TESTING AND TREATMENT
Richard Noel MD, Duke University Medical Center

APFED Outstanding EGID Abstract Award
EMPIRIC FOUR FOOD ELIMINATION DIET INDUCES REMISSION IN PEDIATRIC EOSINOPHILIC ESOPHAGITIS AND SUBSEQUENT REINTRODUCTION IDENTIFIES FOOD TRIGGERS.
Amir Kagalwalla^1,2, Katie Amsden¹, Melanie M. Makhija¹, Joshua B. Wechsler¹, Anthony Olive³, Sally Schwartz¹, Carla Davis³, Kristin Johnson¹, Marion Groetch⁴, Mary Ellen Riffle⁴, Maria Manuel-Rubio¹, Hector Melin-Aldana⁵, Barry Wershil¹, Margaret Collins⁶, Mirna Chehade⁴. ¹Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA; ²Department of Pediatrics, John H. Stroger Hospital of Cook County, Chicago, IL, USA; ³Pediatric Medicine, Texas Children's Hospital, Houston, TX, USA; ⁴Icahn School of Medicine at Mount Sinai, New York, NY, USA; ⁵Department of Pathology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA; ⁶Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

APPROACH TO THE PATIENT WITH DYSPHAGIA: WHEN IT'S NOT EoE…
Manu Sood MD, Children’s Hospital of Wisconsin

APFED Outstanding EGID Abstract Award
CHEMICAL AND MECHANICAL STIMULI DRIVE ESOPHAGEAL FIBROBLAST ACTIVITY: IMPLICATIONS FOR EOE FIBROSIS.
Amanda Muir¹, Kara Dods¹, Alain J. Benitez¹, Steven Henry², Dale Lee³, Kelly Whelan⁴, Maureen DeMarshall⁴, Daniel Hammer², Gary Falk⁴, Rebecca G. Wells⁴, Jonathan Spergel⁵, Hiroshi Nakagawa⁴, Mei-Lun Wang¹. ¹GI, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; ²Department of Engineering, University of Pennsylvania, Philadelphia, PA, USA; ³Gastroenterology, Seattle Children's Hospital, Seattle, WA, USA;⁴Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA; ⁵Allergy, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

HARNESSING THE POWER OF INDIVIDUAL AND ORGANIZED ADVOCACY
Tom Sheridan

THE EFFECTIVE ADVOCATE: A VIEW FROM CAPITOL HILL
Ron Grimes

WHAT DOES IT MEAN TO BE A PATIENT ADVOCATE?
George Ferr

You can now view the full video of the 2015 LASPGHAN Session.

WELCOME BY NASPGHAN'S INTERNATIONAL COMMITTEE
Chair: Miguel Saps MD

INVITATION AND INFORMATION ON LASPGHAN ANNUAL MEETING
Eduardo Hebel, MD, LASPGHAN's President

ABSTRACT AWARD PRESENTATION

NON-CELIAC GLUTEN SENSITIVITY AND FODMAP DIET: MYTH OR REALITY?
Bruno Chumpitazi MD, Texas Children's Hospital

ENDOSCOPIC MANAGEMENT OF GASTROINTESTINAL BLEEDING AND FOREIGN BODIES IN CHILDREN
Antonio J Quiros MD, Medical University of South Carolina

ABSTRACT AWARD PRESENTATION

DEBATE: EOSINOPHILIC ESOPHAGITIS
Moderator: Eduardo Hebel MD
Richard Noel MD, Chief, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Duke University School of Medicine
Samuel Nurko MD, MPH, Director, Center for Motility and Functional Gastrointestinal Disorders, Boston Children's Hospital

NEW ADVANCES: DIAGNOSTIC AND THERAPEUTIC PERSPECTIVES IN EOSINOPHILIC ESOPHAGITIS
Eitan Rubinstein MD, Boston Children's Hospital

ABSTRACT AWARD PRESENTATION

PEDIATRIC NAFLD - CHALLENGES IN CLINICAL CARE

THANKS BUT NO THANKS: DEALING WITH REFUSAL OF MEDICALLY NECESSARY TREATMENT
Sylviane Forget MD and William Wenner MD

CROHN’S DISEASE: COMPLICATED CASES 
Athos Bousvaros MD and Brian P. Regan Sr. DO

MEET THE FDA
Andrew Mulberg MD and Juli Tomaino, MD, Jessica Lee, MD and Kerry Jo Lee, MD

TRANSITION TO TRANSFER OF CARE
Laurie Fishman MD and Nitika Gupta MD

HEPATITIS B 
Phil Rosenthal MD and Douglas Mogul MD

MANAGEMENT OF GASTROINTESTINAL AND NUTRITIONAL MANIFESTATIONS OF CYSTIC FIBROSIS 
Maria Mascarenhas MBBS and Meghana Sathe, MD

HOW TO ACE THE ACE 
Leonel Rodriguez MD, Jason Dranove MD and Sheila Bell

LA B DE HEPATITIS EN NIÑOS (no charge)
Regino Gonzalez Peralta MD and Aymin Delgado-Borrego MD, MP

Fellow Research Award
AN INNOVATIVE MUCOSAL IMPEDANCE DEVICE DIFFERENTIATES ACTIVE EOSINOPHILIC ESOPHAGITIS FROM INACTIVE DISEASE, NERD, AND CONTROLS. 
Mary Allyson Lowry¹, Michael F. Vaezi², Hernan Correa³, Tina Higginbotham², James C. Slaughter⁴, Sari Acra¹.¹Pediatric Gastroenterology, Vanderbilt University, Nashville, TN, USA; ²Gastroenterology, Vanderbilt University, Nashville, TN, USA; ³Pediatric Pathology, Vanderbilt University, Nashville, TN, USA; ⁴Biostatistics, Vanderbilt University, Nashville, TN, USA.

Young Faculty Investigator Award
LOSS OF NUCLEAR RECEPTOR LRH-1 SENSITIZES INTESTINAL EPITHELIUM TO INFLAMMATORY INJURY.
James R. Bayrer¹, Robert Fletterick², Ophir Klein⁴, Holly Ingraham³. ¹Pediatric Gastroenterology, U.C. San Francisco, San Francisco, CA, USA; ²Biochemistry and Biophysics, U.C. San Francisco, San Francisco, CA, USA;³Cellular and Molecular Pharmacology, U.C. San Francisco, San Francisco, CA, USA; ⁴Orofacial Sciences and Pediatrics, U.C. San Francisco, San Francisco, CA, USA.

KEYNOTE ADDRESS: 21^ST CENTURY HEALTH CARE POLITICS AND THE CHALLENGES THEY POSE TO PEDIATRIC ACADEMIC MEDICINE
Atul Grover MD, Association of American Medical Colleges

Young Faculty Clinical Investigator Award
PANTOPRAZOLE PHARMACOKINETICS IN OBESITY: WHERE GENES AND SIZE COLLIDE.
Valentina Shakhnovich^1,2, Susan Abdel-Rahman², Craig Friesen¹, Jaylene Weigel², Robin E. Pearce², Andrea Gaedigk², J Steven Leeder², Gregory L. Kearns². ¹Gastroenterology, Hepatology and Nutrition, Children's Mercy Hospital, Kansas City, MO, USA; ²Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, MO, USA.

William Balistreri Prize
SELECTIVE SEROTONIN REUPTAKE INHIBITORS HAVE CRITICAL AND LONG-LASTING EFFECTS ON ENTERIC NERVOUS SYSTEM DEVELOPMENT AND GASTROINTESTINAL FUNCTION.
Virginia Saurman¹, Korey Stevanovic¹, Narek Israelyan¹, Zi Shan Li², Michael Gershon², Isaac Snyder¹, Kara G. Margolis¹. ¹Pediatrics, Columbia University Medical Center, New York, NY, USA; ²Pathology, Columbia University Medical Center, New York, NY, USA.

Gerald Odell Prize
HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED EXTRACELLULAR VESICLES REVERSE HEPATIC STELLATE CELL ACTIVATION. 
Davide Povero¹, Nidhi Goyal¹, Lucas de Araujo Horcel^1,2, Akiko Eguchi¹, Paulina Ordonez¹, Ariel E. Feldstein¹.¹University of California San Diego, La Jolla, CA, USA; ²Centro Universitario Lusiada, São Paulo, Brazil.

KEYNOTE ADDRESS: PERSPECTIVES FROM NIDDK RELATED TO NASPGHAN
Griffin P. Rodgers MD, MACP, Director, National Institute of Diabetes and Digestive and Kidney Disease

EMBRYOLOGY MEETS ENDOSCOPY: THE ROLE OF ENDOSCOPY IN CONGENITAL GASTROINTESTINAL MALFORMATIONS
Michael Manfredi MD, Children’s Hospital Boston

PEDIATRIC ERCP IN THE SETTING OF ACUTE PANCREATITIS: A REPORT FROM THE MULTICENTER PEDIATRIC ERCP DATABASE INITIATIVE.
David M. Troendle^1,2, Quin Y. Liu^3,4, Kyung Mo Kim^6,5, Doug Fishman^7,8, Matthew Giefer^10,9, Michael Wilsey¹¹, Racha Khalaf¹¹, Bradley A. Barth^1,2. ¹Pediatrics, UT Southwestern, Dallas, TX, USA; ²Children's Health, Children's Medical Center, Dallas, TX, USA; ³University of Southern California, Los Angeles, CA, USA;⁴Children's Hospital of Los Angeles, Los Angeles, CA, USA; ⁵Asan Medical Center Children's Hospital, Seoul, Korea (the Republic of); ⁶University of Ulsan College of Medicine, Seoul, Korea (the Republic of); ⁷Baylor College of Medicine, Houston, TX, USA; ⁸Texas Children's Hospital, Houston, TX, USA; ⁹Seattle Children's Hospital, Seattle, TX, USA; ¹⁰University of Washington, Seattle, WA, USA; ¹¹All Children's Hospital Johns Hopkins Medicine, St. Petersburg, FL, USA.

STATE OF THE ART RESEARCH LECTURE - BUILDING A CAREER IN PEDIATRIC ENDOSCOPY RESEARCH
Petar Mamula MD, Children’s Hospital of Philadelphia

FACTORS ASSOCIATED WITH INADEQUATE BOWEL PREPARATION FOR COLONOSCOPY IN CHILDREN - A PROSPECTIVE STUDY.
Sanjay Kumar, Courtney D. Gingerich, Emily Ferrell, Sandeep K. Gupta. Pediatric Gastroenterology, Riley Hospital for Children - Indiana University Health, Indianapolis, IN, USA.

THREE DIMENSIONAL PRINTING OF HUMAN LIVER FOR SURGICAL PLANNING AND BEYOND
Nizar Zein MD, The Cleveland Clinic

SURVIVAL OUTCOME SCORES (SOFT, BAR AND PEDI-SOFT) ARE ACCURATE IN PREDICTING POST-LIVER TRANSPLANT SURVIVAL IN ADOLESCENTS.
Praveen Kumar Conjeevaram Selvakumar³, Brian Maksimak³, Ibrahim Hanouneh¹, Dalia H. Youssef³, Rocio Lopez², Naim Alkhouri³. ¹Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA;²Biostatistics, Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA; ³Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH, USA.

MECHANISMS OF HEPATIC STEATOSIS: DIAGNOSTIC AND THERAPEUTIC IMPLICATIONS
Ariel Feldstein MD, University of California, San Diego

MIXED LINEAGE KINASE 3 MEDIATES RELEASE OF C-X-C MOTIF CHEMOKINE 10-BEARING EXTRACELLULAR VESICLES FROM LIPOTOXIC HEPATOCYTES. 
Samar H. Ibrahim¹, Petra Hirsova², Steven F. Bronk², Nathan W. Werneberg², Stephen A. Harrison³, Harmeet Malhi², Gregory J. Gores². ¹Pediatric Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA;²Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA; ³Gastoenterology and Hepatology, Brooke Army Medical Center, Fort Sam Houston, TX, USA.

DEBATE: HEAL THE MUCOSA OR HEAL THE PATIENT?
Cary Sauer MD, Emory Children’s Center vs. Shehzad Saeed MD, Cincinnati Children’s Hospital Medical Center

NASPGHAN Foundation/Crohn’s and Colitis Foundation Young Investigator Development Award
A METAGENOMIC APPROACH TO DIAGNOSIS, INDUCTION AND MAINTENANCE OF DEEP REMISSION FOLLOWING EXCLUSIVE ENTERAL NUTRITION IN PEDIATRIC CROHN’S DISEASE 
Johann Van Limbergen MD, MRCPCH, PhD, IWK Health Centre

STATE OF THE ART RESEARCH LECTURE - STATURAL GROWTH IMPAIRMENT IN PEDIATRIC CROHN’S DISEASE
Neera Gupta MD, MAS Weill Cornell Medical Center

NASPGHAN Foundation Fellow to Faculty Transition Award in IBD
OXIDATIVE STRESS AND THE GUT MICROBIOME IN IBD TRANSITION
Lindsey Albenberg MD, Children’s Hospital of Philadelphia

View Speaker Profiles

UPDATE ON CPT CODES AND ALTERNATIVE PAYMENT MECHANISMS 
Joel Brill, MD, FAIR Health, Inc.

PRACTICE ECONOMICS: MISSION, MONEY, MIDAS AND MAGIC
David A. Piccoli MD, Children’s Hospital of Philadelphia

NASPGHAN WORKFORCE SURVEY RESULTS: HOW DO WE ALL STACK UP? 
Linda Muir MD, FAAP, Oregon Health Science University

REGULATORY CONSIDERATIONS IN SELECTING AN ENDPOINT
Preeti Venkataraman MD, Food and Drug Administration

EUROPEAN MEDICINES AGENCY (EMA) PERSPECTIVE ON THE DEVELOPMENT OF NEW MEDICINES IN GASTROENTEROLOGY 
Richard Veselý MD, European Medicines Agency, London, UK

CLINICALLY MEANINGFUL ENDPOINTS IN EoE
Glenn Furuta MD, Children’s Hospital Colorado

NUTRITIONAL ISSUES IN CHOLESTATIC DISEASE
Binita Kamath MBBChir MRCP MTR, The Hospital for Sick Children

NUTRITIONAL CHALLENGES IN CHILDREN WITH AUTISM
Cade M. Nylund, MD, MS, F. Edward Hébert School of Medicine Uniformed Services University

IRON DEFICIENCY AND THE DEVELOPING BRAIN 
Michael Georgieff MD, University of Minnesota

“ISLET” THEM TAKE MY WHOLE PANCREAS!
Jaimie Nathan MD, Cincinnati Children’s Hospital Medical Center

EARLY ENTERAL NUTRITION AND AGRESSIVE FLUID RESUSCITATION ARE ASSOCIATED WITH IMPROVED CLINICAL OUTCOMES IN ACUTE PANCREATITIS. 
Flora K. Szabo, Lin Fei, Ligia M. Alfaro Cruz, Maisam Abu-El-Haija. Cincinnati Children's Hospital, Cincinnati, OH, USA.

STATE OF THE ART RESEARCH LECTURE - SOLVING A PEDIATRIC DILEMMA: DRUG-INDUCED PANCREATITIS 
Sohail Husain MD, Children's Hospital of Pittsburgh of UPMC & the University of Pittsburgh

NASPGHAN Pancreas Prize –Supported by a grant from JOLI Diagnostic
TARGETING PANCREATIC CALCINEURIN TO PREVENT POST-ERCP PANCREATITIS.
Abrahim I. Orabi, Tanveer A. Javed, Swati Sah, John F. Eisses, Shunqian Jin, Sohail Z. Husain. Pediatric Gastroenterology, University of Pittsburgh, Pittsburgh, PA, USA.

BRAIN-GUT INTERACTIONS: IMPLICATIONS IN NEUROGASTROENTEROLOGY
Kara Gross Margolis MD, Columbia University

NASPGHAN Motility Prize – Basic Science –Supported by a grant from MMS
IBUPROFEN SLOWS MIGRATION OF ENTERIC NERVOUS SYSTEM PRECURSOR CELLS INCREASING THE RISK OF HIRSCHSPRUNG-LIKE DISEASE IN ANIMAL MODELS. 
Ellen M. Schill^1,2, Jonathan I. Lake², Olga Tusheva², Nandor Nagy^4,5, Saya K. Bery¹, Lynne Foster⁶, Marina Avetisyan², Stephen L. Johnson³, William F. Stenson⁶, Allan M. Goldstein⁴, Robert O. Heuckeroth¹. ¹Pediatrics, The Children's Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; ²Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; ³Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA;⁴Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; ⁵Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Budapest, Hungary; ⁶Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.

THE OVERLAP BETWEEN INFLAMMATORY BOWEL DISEASE AND FUNCTIONAL GASTROINTESTINAL DISORDERS: CHALLENGES AND TREATMENT IMPLICATIONS 
Miguel Saps MD, Nationwide Children’s Hospital

NASPGHAN Motility Prize – Clinical Science – Supported by a grant from MMS
PARENT-ONLY INTERVENTION REDUCES SYMPTOMS AND DISABILITY IN ABDOMINAL PAIN PATIENTS. 
Rona L. Levy¹, Miranda Van Tilburg², Shelby L. Langer¹, Joan M. Romano³, Lloyd A. Mancl⁴, William E. Whitehead², Shara A. Feld⁵, Lynn S. Walker⁶. ¹School of Social Work, University of Washington, Seattle, WA, USA; ²Medicine, University of North Carolina, Chapel Hill, NC, USA; ³Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA; ⁴Oral Health Sciences, University of Washington, Seattle, WA, USA; ⁵School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; ⁶Pediatrics, Vanderbilt University, Nashville, TN, USA.

IBD: IF MY PATIENT IS WELL ON COMBINATION THERAPY WHAT SHOULD I DO? BE HAPPY OR DE-ESCALATE THERAPY? 
Andrew Grossman MD, Children’s Hospital of Philadelphia

LIVER TRANSPLANT AND IMMUNOSUPPRESSION: LESS OR NONE,SAFE OR SORRY? 
Sandy Feng MD, PhD, University of California, San Francisco

SHOULD I TREAT EOSINOPHILIC ESOPHAGITIS AS A CHRONIC DISEASE? 
Glenn Furuta MD, Children’s Hospital Colorado

PSYCHOSOCIAL ASPECTS OF CHRONIC GASTROENTEROLOGICAL ILLNESS
Bonnie Reed-Knight PhD, Emory University School of Medicine

WHAT HAPPENS BEHIND CLOSED DOORS: THE INS AND OUTS OF PSYCHOLOGICAL TREATMENTS 
Katherine Lamparyk Pys.D, Cleveland Clinic Children’s

PSYCHOLOGY AND GASTROENTEROLOGY: KEYS TO EFFECTIVE INTEGRATION
Anthony Alioto PhD, BCB, Nationwide Children’s Hospital

IMPROVE CARE NOW: EXPANDING ON A DECADE OF LEARNING
Wallace Crandall MD, Nationwide Children’s Hospital

GENETIC VARIATION IN VERY EARLY ONSET INFLAMMATORY BOWEL DISEASE. 
Christopher J. Moran¹, Judith Kelsen², Jess L. Kaplan1, Hailiang Huang⁸, Manuel Rivas⁸, Noor Dawany⁹, Melvin B. Heyman³, Barbara Kirschner⁴, Thomas Mangatu⁴, Keith Benkov⁶, Jonathan E. Teitelbaum⁷, Stan Cohen12, Benjamin D. Gold12, Marcella Devoto10, Ramnik Xavier11, Robert Baldassano², Mark J. Daly⁵, Harland S. Winter¹. ¹Pediatric Gastroenterology, MassGeneral Hospital for Children, Boston, MA, USA;²Pediatric Gastroenterology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; ³Pediatric Gastroenterology, University of California, San Francisco, San Francisco, CA, USA; ⁴Pediatric Gastroenterology, The University of Chicago Medicine Comer Children's Hospital, Chicago, IL, USA; ⁵Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA; ⁶Pediatric Gastroenterology, The Mount Sinai Hospital, New York, NY, USA; ⁷Pediatric Gastroenterology, Monmouth Medical Center, Long Branch, NJ, USA; ⁸Broad Institute, Cambridge, MA, USA; ⁹Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; ¹⁰Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; ¹¹Gastroenterology, Massachusetts General Hospital, Boston, MA, USA; ¹²Children's Center for Digestive Health Care, Atlanta, GA, USA.

HEALTH MAINTENANCE OF IBD (VACCINATION/SKIN)
Paul Rufo MD, Children’s Hospital Boston

NASPGHAN Foundation Fellow to Faculty Transition Award in IBD
CMV INFECTION IN INDIVIDUALS WITH NK CELL LICENSING GENOTYPE PREDISPOSESTO INFLAMMATORY BOWEL DISEASE 
Susy Yusung MD, Children’s Hospital, Los Angeles

LONG TERM MANAGEMENT OF THE POST PEDIATRIC LIVER TRANSPLANT PATIENT: SOMETHING FOR EVERYONE TO CARE ABOUT 
Vicky Lee Ng MD, The Hospital for Sick Children

MICRORNA-181 PROMOTES GRAFT PROLONGATION BY PLASMACYTOID DENDRITIC CELLS BY INCREASING T REGULATORY CELLS AND DECREASING B CELLS AS REVEALED BY MASS CYTOMETRY (CYTOF). 
Audrey H. Lau¹, Matthew Vitalone², Xiumei Qu², Todd Shawler², Olivia M. Martinez², Carlos O. Esquivel², Sheri M. Krams². ¹Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, LPCH/Stanford University, Stanford, CA, USA; ²Surgery, Stanford University, Stanford, CA, USA.

STATE OF THE ART RESEARCH LECTURE - UNIQUE ASPECTS OF NEONATAL IMMUNITY PROVIDE CLUES TO THE PATHOGENESIS OF BILIARY ATRESIA
Cara Mack MD, Children’s Hospital of Colorado

PROSPECTIVE ANALYSIS OF PRESENTING FEATURES OF NEONATAL CHOLESTASIS – LIMITATIONS IN PREDICTIVE MODELS OF BILIARY ATRESIA. 
Benjamin Shneider¹, John C. Magee², Nanda Kerkar⁴, Jeffrey Moore⁵, Wen Ye⁵, Saul Karpen³, Peter Whitington⁶, Jorge Bezerra⁷, Paula Hertel¹, Jean Molleston⁸, Kasper Wang⁹, Henry Lin¹⁰, Robert Squires¹¹, Philip Rosenthal¹², Vicky Ng¹³, Yumirle Turmelle¹⁴, Kathleen Schwarz¹⁵, Averell Sherker¹⁶, Ronald J. Sokol for ChiLDReN¹⁷. ¹Pediatric Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine, Houston, TX, USA; ²University of Michigan Medical School, Ann Arbor, MI, USA; ³Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine/Children's Healthcare of Atlanta, Atlanta, GA,USA;⁴Division of Gastroenterology, Hepatology and Nutrition, Childrens' Hospital of Los Angeles, University of Southern California, Los Angeles, CA, USA; ⁵Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA; ⁶Pediatrics Division of Gastroenterology, Hepatology, and Nutrition,Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA; ⁷Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; ⁸Department of Pediatrics, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Indiana University School of Medicine, Indianapolis, IN, USA; ⁹Division of Pediatric Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA;¹⁰Children's Hospital of Philadelphia, Philadelphia, PA, USA; ¹¹Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; ¹²Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, UCSF Benioff Children's Hospital, San Francisco, CA, USA; ¹³The Hospital for Sick Children, Toronto, ON, Canada;¹⁴Washington University School of Medicine, Saint Louis, MO, USA; ¹⁵Johns Hopkins School of Medicine, Baltimore, MD, USA; ¹⁶Liver Diseases Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA; ¹⁷Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.

NERD: A FOUR LETTER WORD?
Rachel Rosen MD, Boston Children’s Hospital

CLAUDIN-7 DYSREGULATION IN PEDIATRIC EOSINOPHILIC ESOPHAGITIS: A ROLE FOR TGF-β1 IN ESOPHAGEAL EPITHELIAL BARRIER DYSFUNCTION.
Shahan D. Fernando¹, Kathryn A. Biette¹, David A. Kitzenberg², Louise E. Glover², Sean P. Colgan², Glenn Furuta¹, Joanne C. Masterson¹. ¹Pediatrics, University of Colorado, Denver, CO, USA; ²Medicine, University of Colorado, Denver, CO, USA.

STATE OF THE ART RESEARCH LECTURE - MANIPULATING GUT BACTERIA TO PREVENT THE ONSET OF CELIAC DISEASE
Alessio Fasano MD, Massachusetts General Hospital for Children

NON-INVASIVE MONITORING OF INTESTINAL PERMEABILITY AND INFLAMMATION IN A PROSPECTIVE SEROLOGICAL DIAGNOSIS STUDY OF PEDIATRIC CELIAC DISEASE.
Seema Rajani¹, Hien Q. Huynh^1,2, Leanne Shirton², Cheryl Kluthe², Don Spady¹, Connie Prosser⁵, Jon Meddings⁴, Gwendolyn Rempel³, Rabindranath Persad^1,2, Justine Turner^1,2. ¹Pediatrics, University of Alberta, Edmonton, AB, Canada; ²Gastroenterology, Stollery Children's Hospital, Edmonton, AB, Canada; ³Nursing, University of Alberta, Edmonton, AB, Canada; ⁴Medicine, University of Calgary, Calgary, AB, Canada; ⁵Stollery Children's Hospital, Edmonton, AB, Canada.

ABDOMINAL PAIN: INTEGRATING PSYCHOLOGICAL TREATMENTS INTO MEDICAL CARE 
Miranda vanTilburg PhD, University of North Carolina

CONSTIPATION AND SOILING: INTEGRATED MODELS OF CARE 
Rose Schroedl PhD, Nationwide Children's Hospital

INTERDISCIPLINARY INPATIENT APPROACHES TO WEANING TUBE DEPENDENT CHILDREN FROM ENTERAL FEEDING 
Alan Silverman PhD, Medical College of Wisconsin

WHEN IS INFORMED CONSENT REALLY INFORMED? 
Jeannie Huang MD, University of California, San Diego

ETHICS AND ADVOCACY IN THE MODERN ERA OF PEDIATRIC LIVER TRANSPLANTATION IN THE UNITED STATES 
Evelyn Hsu MD, Seattle Children's Hospital

THE ETHICS OF INVESTIGATIONAL AND COMPASSIONATE USES 
Kevin Donovan MD, Georgetown School of Medicine